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A Phase I Study of BI 905677 in Patients with Advanced ...

    https://www.mskcc.org/cancer-care/clinical-trials/18-525
    Full Title An Open-label, Phase I Trial to Determine the Maximum-Tolerated Dose and Investigate Safety, Pharmacokinetics and Efficacy of BI 905677 Administered Intravenously in Patients with Advanced Solid Tumours Purpose The purpose of this study is to find the highest dose of the investigational drug BI 905677 that can be given safely in patients with persistent or inoperable solid tumors ...

Abstract DDT01-01: BI 905677: A first-in-class LRP5/6 ...

    https://cancerres.aacrjournals.org/content/79/13_Supplement/DDT01-01
    Jul 01, 2019 · BI 905677 is a highly potent blocker of signalling induced by the Wnt family of ligands and shows anti-tumor activity in cancer models harbouring genomic alterations in upstream regulators of the Wnt pathway, such as RNF43 mutations or RSPO fusions.Author: Vittoria Zinzalla, Barbara Drobits-Handl, Alexander Savchenko, Jörg Rinnenthal, Markus Johann Bauer,...

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